Nọmba Cas: 144701-48-4 Fọọmu Molecular: C33H30N4O2

Apejuwe kukuru:

Cas nọmba: 144701-48-4
Orukọ Kemikali:
Fọọmu Molecular: C33H30N4O2

Awọn itumọ ọrọ-ọrọ: MICARDIS; TU-199; Telmisaran; TIMISHATAN; 2-(4-{[4-Methyl-6-(1-Methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1 ,3-benzodiazol-1-yl]Methyl}phenyl) benzoic acid; 4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl ][1,1'-biphenyl] -2-carboxylic acid, BIBR 277; PRITOR; BIBR 277; misartan; BIBR 277SE

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Alaye ọja

ọja Tags

Awọn ọja Specification

Ojuami Iyo	261-263°C
iwuwo	1.16 (iṣiro ti o ni inira)
iwọn otutu ipamọ	Afẹfẹ inert,Iwọn otutu yara 2-8°C
solubility	DMSO:> 5 mg/ml ni 60 °C
opitika aṣayan iṣẹ-ṣiṣe	N/A
Ifarahan	Pa-White Ri to
Mimo	≥98%

Apejuwe

ti ṣe ifilọlẹ ni AMẸRIKA fun itọju haipatensonu.O le ṣetan ni awọn igbesẹ mẹjọ ti o bẹrẹ pẹlu methyl 4-amino-3-methyl benzoate;cyclization akọkọ ati keji sinu oruka benzimidazole waye ni awọn igbesẹ 4 ati 6 ni atele.ṣe idiwọ iṣẹ ti angiotensin II (Ang II), moleku ipa akọkọ ti eto renin-angiotensin-aldosterone (RAAS).O jẹ idamẹfa ti kilasi 《sartans》 lati wa fun tita lẹhin agbo ogun Losartan.Ipa pipẹ rẹ (igbesi aye idaji wakati 24) le jẹ iyatọ akọkọ pẹlu awọn antagonists angiotensin II miiran.Ko dabi ọpọlọpọ awọn aṣoju miiran ninu ẹka yii, iṣẹ ṣiṣe ko dale lori iyipada sinu metabolite ti nṣiṣe lọwọ, 1-O-acylglucuronide jẹ metabolite akọkọ ti a rii ninu eniyan. angiotensin II lakoko ti o ko ni ibatan fun awọn iru-ẹya AT2 tabi awọn olugba miiran ti o ni ipa ninu ilana eto inu ọkan ati ẹjẹ.Ni ọpọlọpọ awọn ẹkọ ile-iwosan, ni iwọn lilo lẹẹkan lojoojumọ, ṣe agbejade awọn ipa idinku titẹ ẹjẹ ti o munadoko ati iduroṣinṣin pẹlu iṣẹlẹ kekere ti awọn ipa ẹgbẹ (paapaa ikọlu itọju ti o ni ibatan pẹlu awọn inhibitors ACE ni awọn alaisan agbalagba).