Nọmba Rifampicin Cas: 13292-46-1 Fọọmu Molecular: C43H58N4O12

Apejuwe kukuru:

Orukọ Kemikali:Rifampicin

Fọọmu Molecular:
C43H58N4O12

Awọn itumọ ọrọ: 9,17,19,21-hexahydroxy-23-methoxy-2,4,12,1///;2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11 (2-h) -dione,5,6;3-(((4-methyl-1-piperazinyl)imino)methyl)-rifamyci;3-((4-methyl-1-piperazinyl) iminomethyl ) rifamycinsv; 8- (((4-methyl-1-piperazinyl) imino)methyl) rifamycinsv; 8- (4-Methylpiperazinyliminomethyl) rifamycinSV; 8- (n- (4-methyl-1-piperazinyl) formidoyl) -rifomycins; RIFAMPIN “LEPETIT”

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Alaye ọja

ọja Tags

Awọn ọja Specification

Ojuami Iyo	183 °
iwuwo	1.1782 (iṣiro ti o ni inira)
iwọn otutu ipamọ	2-8°C
solubility	chloroform: soluble50mg/ml, ko o
opitika aṣayan iṣẹ-ṣiṣe	N/A
Ifarahan	pupa pupa si pupa dudu pupọ
Mimo	≥99%

Apejuwe

Rifampicin jẹ itọsẹ semisynthetic ti rifamicin B, aporo aporo macrolactam ati ọkan ninu diẹ sii ju marun awọn oogun aporo ajẹsara ti rifamicins A, B, C, D, ati E, eyiti a pe ni eka rifamicin, eyiti o jẹ iṣelọpọ nipasẹ actinomycetes Streptomyces mediteranei ( Nocardia mediteranei).O ti ṣe sinu iṣe iṣoogun ni ọdun 1968. Agbepọ ti rifampicin bẹrẹ pẹlu ojutu olomi ti rifamicin, eyiti labẹ awọn ipo ifaseyin jẹ oxidized si itọsẹ tuntun ti rifamicin S (32.7.4), pẹlu idasile agbedemeji ti rifamicin O (32.7. 3).Idinku ilana quinone ti ọja yii pẹlu hydrogen ni lilo palladium kan lori ayase erogba yoo fun rifamicin SV (32.7.5).Ọja ti o mu jade gba aminomethylation nipasẹ adalu formaldehyde ati pyrrolidine, fifun 3-pyrrolidinomethylrifamicin SV (32.7.6).Oxidizing ọja abajade pẹlu tetracetate asiwaju si enamine ati hydrolysis ti o tẹle pẹlu ojutu olomi ti ascorbic acid yoo fun 3-formylrifamicin SV (32.7.7).Idahun si eyi pẹlu 1-amino-4-methylpiperazine yoo fun rifampicin ti o fẹ (32.7.8).

lilo ati doseji

A lo Rifampin bi oogun apakokoro.O jẹ itọsẹ semisynthetic ti rifamycin B, oogun aporo ajẹsara macrocyclic ti a ṣe nipasẹ mimu Streptomyces mediterranei.A lo Rifampin fun itọju ikọ-igbẹ, brucellosis, Staphlococcus aureus, ati awọn arun ajakale-arun miiran.