Nọmba Cas: 21187-98-4 Molecular Formula ifihan Aworan

Cas nọmba: 21187-98-4 Molecular Formula

Apejuwe kukuru:

Cas nọmba: 21187-98-4

Orukọ Kemikali:

Fọọmu Molecular: C15H21N3O3S

Awọn itumọ ọrọ: BP; -4-methyl-; 1- (3-azabicyclo (3.3.0) oct-3-yl) -3- (p-tolylsulfonyl) urea; 1- (hexahydrocyclopenta (c) pyrrol-2 (1h) -yl) -3- (p-tolylsulfonyl) -ure; 1- (hexahydrocyclopenta (c) pyrrol-2 (1h) -yl)-3- (p-tolylsulfonyl) urea; benzenesulfonamide, n-( ((hexahydrocyclopenta() c) pyrrol-2 (1h) -yl) amino) carbonyl; n- (4-methylbenzenesulfonyl) -n'- (3-azabicyclo (3.3.0) oct-3-yl) urea; Tetrabenzyl Voglibose HCl

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Alaye ọja

ọja Tags

Awọn ọja Specification

Ojuami Iyo	163-169 °C
iwuwo	1.2205 (iṣiro ti o ni inira)
iwọn otutu ipamọ	Afẹfẹ inert,Iwọn otutu yara 2-8°C
solubility	methylene kiloraidi: tiotuka
opitika aṣayan iṣẹ-ṣiṣe	N/A
Ifarahan	Pa-White Ri to
Mimo	≥98%

Apejuwe

jẹ aṣoju antihyperglycemic oral ti a lo fun itọju ti àtọgbẹ mellitus iru II.O jẹ ti kilasi sulfonylurea ti awọn aṣiri insulini, eyiti o mu ki awọn sẹẹli β ti oronro ṣiṣẹ lati tu insulin silẹ.sopọ mọ β cell sulfonyl urea receptor (SUR1), siwaju didi awọn ikanni potasiomu ifarabalẹ ATP.Nitoribẹẹ, itujade potasiomu n dinku pupọ, ti o fa idinku awọn sẹẹli beta kuro.Lẹhinna awọn ikanni kalisiomu ti o gbẹkẹle foliteji ninu sẹẹli β wa ni ṣiṣi, ti o mu ṣiṣẹ calmodulin, eyiti o yori si exocytosis ti hisulini ti o ni awọn granules ikọkọ.Awọn ijinlẹ aipẹ tun ti fihan pe o le mu imudara ipo anti-oxidant ati nitric oxide-mediated vasodilation ninu àtọgbẹ Iru 2 ati daabobo awọn sẹẹli beta pancreatic lati ibajẹ nipasẹ hydrogen peroxide.

lilo ati doseji

jẹ aṣoju hypoglycemic oral ti a lo lati ṣe itọju àtọgbẹ mellitus ti ko ni igbẹkẹle-insulin.Itọju àtọgbẹ ti o ni nkan ṣe pẹlu isanraju tabi arun ti iṣan, fun awọn agbalagba ti o ni àtọgbẹ 2 iru. ounje sinu agbara.dinku awọn ipele glukosi ẹjẹ nipasẹ jijẹ yomijade hisulini lati awọn sẹẹli beta ti awọn erekusu Langerhans.