Nọmba Cas: 330784-47-9 Fọọmu Molecular: C23H26ClN7O3 Aworan Ifihan

Nọmba Cas: 330784-47-9 Molecular Formula: C23H26ClN7O3

Apejuwe kukuru:

Cas nọmba: 330784-47-9

Orukọ Kemikali:

Fọọmu Molecular: C23H26ClN7O3

Awọn itumọ ọrọ: (S) -2- (2-Hydroxymethyl-1-pyrrolidinyl) -4- (3-chloro-4-methoxybenzylamino) -5-[(2-pyrimidinylmethyl)carbamoyl] pyrimidine

4-[(3-Chloro-4-methoxybenzyl) amino] -2- [2- (hydroxymethyl) -1-pyrrolidinyl] -N- (2-pyrimidinylmethyl) -5-pyrimidinecarboxamide

Fi imeeli ranṣẹ si wa

Alaye ọja

ọja Tags

Awọn ọja Specification

Ojuami Iyo	150-152°C
iwuwo	1.372
iwọn otutu ipamọ	Ti di ni gbigbẹ, fipamọ sinu firisa, labẹ -20 ° C
solubility	DMSO (Diẹ), kẹmika (Diẹ, Kikan)
opitika aṣayan iṣẹ-ṣiṣe	N/A
Ifarahan	Funfun to Pa-White
Mimo	≥98%

pharmacodynamics

(Zepeed) ti fọwọsi nipasẹ Ile-iṣẹ Ilera ti Korea fun itọju ti aiṣedeede erectile (ED) ni Oṣu Kẹjọ ọdun 2011. jẹ oludena 5 phosphodiesterase ti o yan pupọ (PDE5).ti royin pe o jẹ oludaniloju PDE5 ti o yan julọ lori ọja naa.Ibẹrẹ Tmax ati idaji-aye tun yatọ laarin awọn inhibitors PDE5 ti o ta ọja.Sildenafil ni T_{o pọju}ni 1 wakati ati idaji-aye ti 3-5 wakati.Vardenafil jẹ iru kanna pẹlu T_{o pọju}ti 0.6 wakati ati idaji-aye ti 4-6 wakati.Tadalafil ni igbesi aye idaji to gunjulo laarin awọn oogun ti o ta ọja pẹlu idaji-aye ti 17 h.ni iyara ibẹrẹ ti igbese de ọdọ T_{o pọju}ni 0,6 h pẹlu kan idaji-aye ti 1,2 h.Akopọ ti (TA-1790) ti wa ni apejuwe ninu awọn iwe-itọsi.Ọna imukuro akọkọ jẹ nipasẹ bile ati feces.ni a tun rii pe o tun pada nipasẹ isọdọtun enterohepatic.